Type 1 regulatory T cells (Tr1) in autoimmunity
نویسندگان
چکیده
منابع مشابه
Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes
Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...
متن کاملthe effect of il-22 and il-28 in induction of type 1 regulatory t (tr1) cells.
cytokines have been introduced as critical inducers in the development of th subpopulations.cytokines like il-10 are involved in inducing regulatory t cells such as type 1 regulatory t (tr1) cells cells. il-22 is a member of il-10 family of cytokines, and il-28a is a member of ifn-γ family. in this study, cord blood mononuclear cells (cbmc) from normal healthy individuals were isolated by ficol...
متن کاملTr1-Like T Cells – An Enigmatic Regulatory T Cell Lineage
The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process. These include a subset of Foxp3(-) CD4(+) T cells able to secrete IL-10 in an antigen-specific manner, type 1 regulatory (Tr1) T cells. Although their suppressive function has been confirmed both in vitro and in vivo, their phenot...
متن کاملRole of regulatory T-cells in autoimmunity.
There has been considerable historical interest in the concept of a specialist T-cell subset which suppresses over-zealous or inappropriate T-cell responses. However, it was not until the discovery that CD4(+)CD25(+) T-cells had suppressive capabilities both in vitro and in vivo that this concept regained credibility and developed into one of the most active research areas in immunology today. ...
متن کاملHarnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes.
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing β-cells in the pancreatic islets. There is an immediate need to restore both β-cell function and immune tolerance to control disease progression and ultimately cure T1D. Currently, there is no effective treatment strategy to restore glucose regulation in patients with T1D. FoxP3-expressing CD4(+) regulatory T cells (...
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ژورنال
عنوان ژورنال: Seminars in Immunology
سال: 2011
ISSN: 1044-5323
DOI: 10.1016/j.smim.2011.07.005